A p53 reactivator
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NSC 59984

Item No. 19919

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(4-methyl-1-piperazinyl)-3-(5-nitro-2-furanyl)-2-propen-1-one
CAS Number
803647-40-7
Molecular Formula
C12H15N3O4
Formula Weight
265.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 10 mg/mlEthanol: 5 mg/ml
λmax
237, 276, 350 nm
SMILES
CN1CCN(C(/C=C/C2=CC=C([N+]([O-])=O)O2)=O)CC1
InChi Code
InChI=1S/C12H15N3O4/c1-13-6-8-14(9-7-13)11(16)4-2-10-3-5-12(19-10)15(17)18/h2-5H,6-9H2,1H3/b4-2+
InChi Key
QKTRIGNWBRHBFV-DUXPYHPUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

    $95

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    10 mg

    $169

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    25 mg

    $378

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    Cayman Chemical
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    Product Description

    NSC 59984 is a reactivator of p53 that restores wild-type p53 signaling by activating p73-dependent apoptosis in mutant p53-expressing colon cancer cells.1 It is reported to induce cell death in colon cancer cells (EC50 = 8.38 µM in p53-null HCT116 cells) without evident toxicity toward normal cells.1 NSC 59984 has been shown to induce p53 mutant protein degradation via MDM2-mediated ubiquitination.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhang, S., Zhou, L., Hong, B., et al. Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor Effects against Colorectal Cancer via p73 Activation and Degradation of Mutant p53. Cancer Res. 75(18), 3842-3852 (2015).