An inducer of Oct3/4
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O4I1

Item No. 19935

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[(4-methoxyphenyl)methoxy]-benzeneacetonitrile
CAS Number
175135-47-4
Molecular Formula
C16H15NO2
Formula Weight
253.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2)(1:5): 0.16 mg/mlEthanol: slightly
λmax
228, 273 nm
SMILES
COC(C=C1)=CC=C1COC2=CC=C(CC#N)C=C2
InChi Code
InChI=1S/C16H15NO2/c1-18-15-6-4-14(5-7-15)12-19-16-8-2-13(3-9-16)10-11-17/h2-9H,10,12H2,1H3
InChi Key
QJEJLARVLKHYFW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $55

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    10 mg

    $103

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    25 mg

    $190

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    50 mg

    $322

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    Product Description

    O4I1 is an inducer of Oct3/4 expression and translation in diverse human cell lines (increases Oct3/4 mRNA in HEK293 cells by 2.5- and 4-fold at 10 and 20 μM, respectively).1 It also induces Oct3/4 expression and translation in terminally differentiated human fibroblasts.1 Through this action, O4I1 promotes the expression of pluripotency-associated genes in human neonatal foreskin fibroblasts.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cheng, X., Dimou, E., Alborzinia, H., et al. Identification of 2-[4-[(4-Methoxyphenyl)methoxy]-phenyl]acetonitrile and derivatives as potent Oct3/4 inducers. J. Med. Chem. 58(12), 4976-4983 (2015).