An inhibitor of human neuraminidases
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N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid

Item No. 19939

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(acetylamino)-2,6-anhydro-3,5-dideoxy-D-glycero-D-galacto-non-2-enonic acid
CAS Number
24967-27-9
Synonyms
  • DANA
Molecular Formula
C11H17NO8
Formula Weight
291.3
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.1 mg/mlDMSO: 1 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
243 nm
SMILES
OC(C1=C[C@H](O)[C@@H](NC(C)=O)[C@@]([C@H](O)[C@H](O)CO)([H])O1)=O
InChi Code
InChI=1S/C11H17NO8/c1-4(14)12-8-5(15)2-7(11(18)19)20-10(8)9(17)6(16)3-13/h2,5-6,8-10,13,15-17H,3H2,1H3,(H,12,14)(H,18,19)/t5-,6+,8+,9+,10+/m0/s1
InChi Key
JINJZWSZQKHCIP-UFGQHTETSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $128

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    10 mg

    $235

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    Product Description

    N-acetyl-2,3-dehydro-2-Deoxyneuraminic acid (DANA) is an inhibitor of human neuraminidases (sialidases) NEU1-4 (IC50s = 143, 43, 61, and 74 μM, respectively).1 In vivo, DANA (30 μl of a 5 mM solution) reduces latency to first seizure and increases seizure duration in a rat model of potassium-induced seizures.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Magesh, S., Moriya, S., Suzuki, T., et al. Design, synthesis, and biological evaluation of human sialidase inhibitors. Part 1: Selective inhibitors of lysosomal sialidase (NEU1). Bioorg. Med. Chem. Lett. 18(2), 532-537 (2008).

    2. Isaev, D., Isaeva, E., Shatskih, T., et al. Role of extracellular sialic acid in regulation of neuronal and network excitability in the rat hippocampus. J. Neurosci. 27(43), 11587-11594 (2007).