An autoregulative inhibitor of spore germination
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Germicidin A

Item No. 19971

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(S)-6-(sec-butyl)-3-ethyl-4-hydroxy-2H-pyran-2-one
Molecular Formula
C11H16O3
Formula Weight
196.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: SolubleDMSO: SolubleEthanol: SolubleMethanol: Soluble
SMILES
O=C1OC([C@@H](C)CC)=CC(O)=C1CC
InChi Code
InChI=1S/C11H16O3/c1-4-7(3)10-6-9(12)8(5-2)11(13)14-10/h6-7,12H,4-5H2,1-3H3/t7-/m0/s1
InChi Key
NPQKQKITPJTEBK-ZETCQYMHSA-N
Origin
Bacterium/Streptomyces sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $242

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    5 mg

    $1,083

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    Product Description

    Germicidin A is a pyranone originally derived from S. viridochromogenes that acts as a reversible, autoregulative inhibitor of spore germination and hyphal elongation in the genus Streptomyces at concentrations as low as 200 pM.1,2 During germination, spores of Streptomyces excrete germicidin A along with other germicidin homologs, which inhibit germination of its own arthrospores.1,2 At higher concentrations, germicidin A can inhibit the porcine Na+/K+-activated ATPase (ID50 = 100 µM) and prevent the germination of the cress L. sativum.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Petersen, F., and Zähner, H. Germicidin, an autoregulative germination inhibitor of Streptomyces viridochromogenes NRRL B-1551. J. Antibiot. (Tokyo) 46(7), 1126-1138 (1993).

    2. Aoki, Y., Matsumoto, D., Kawaide, H., et al. Physiological role of germicidins in spore germination and hyphal elongation in Streptomyces coelicolor A3(2). J. Antibiot. (Tokyo) 64(9), 607-611 (2016).