An IKs and ICTFR blocker
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Chromanol 293B

Item No. 19993

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
rel-N-[(3R,4S)-6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-ethanesulfonamide
CAS Number
163163-23-3
Synonyms
  • Chromanol 239B
Molecular Formula
C15H20N2O4S
Formula Weight
324.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 2 mg/ml
λmax
252 nm
SMILES
CC1(C)[C@H](O)[C@@H](N(S(CC)(=O)=O)C)C2=C(C=CC(C#N)=C2)O1
InChi Code
InChI=1S/C15H20N2O4S/c1-5-22(19,20)17(4)13-11-8-10(9-16)6-7-12(11)21-15(2,3)14(13)18/h6-8,13-14,18H,5H2,1-4H3/t13-,14+/m0/s1
InChi Key
HVSJHHXUORMCGK-UONOGXRCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $36

    Add

    5 mg

    $128

    Add

    10 mg

    $186

    Add

    50 mg

    $667

    Add
    Product Description

    Chromanol 293B is a blocker of slowly activating delayed-rectifier K+ current (IKs) with an IC50 value of 6.89 μM in Xenopus oocytes expressing rat IKs channels.1 It is selective, having no activity at rat Kv1.1 or Kir2.1 channels at a concentration of 30 μM. Chromanol 293B increases the rate and extent of IKs in guinea pig ventricular cells in a dose-dependent manner.2 It also inhibits cystic fibrosis transmembrane conductance regulator (CTFR) Cl- currents (ICTFR) with an IC50 value of 19 μM in Xenopus oocytes expressing human CTFR.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Suessbrich, H., Bleich, M., Ecke, D., et al. Specific blockade of slowly activating IsK channels by chromanols -- Impact on the role of IsK channels in epithelia. FEBS Lett. 396(2-3), 271-275 (1996).

    2. Fujisawa, S., K., O., and Iijima, T. Time-dependent block of the slowly activating delayed rectifier K+ current by chromanol 293B in guinea-pig ventricular cells. Br. J. Pharmacol. 129(5), 1007-1013 (2000).

    3. Bachmann, A., Quast, U., and Russ, U. Chromanol 293B, a blocker of the slow delayed rectifier K+ current (IKs), inhibits the CFTR Cl- current. Naunyn Schmiedebergs Arch. Pharmacol. 363(6), 590-596 (2001).