A small molecule inhibitor of MDMX
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SJ 172550

Item No. 19999

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[2-chloro-4-[(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)methyl]-6-ethoxyphenoxy]-acetic acid, methyl ester
CAS Number
431979-47-4
Synonyms
  • MDMX Inhibitor II
Molecular Formula
C22H21ClN2O5
Formula Weight
428.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS(pH7.2) (1:2): 0.33 mg/mlDMSO: 10 mg/mlEthanol: slightly
λmax
251, 343 nm
SMILES
ClC1=CC(/C=C2C(N(C3=CC=CC=C3)N=C\2C)=O)=CC(OCC)=C1OCC(OC)=O
InChi Code
InChI=1S/C22H21ClN2O5/c1-4-29-19-12-15(11-18(23)21(19)30-13-20(26)28-3)10-17-14(2)24-25(22(17)27)16-8-6-5-7-9-16/h5-12H,4,13H2,1-3H3/b17-10-
InChi Key
RKKFQJXGAQWHBZ-YVLHZVERSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Cayman Chemical
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    Product Description

    SJ 172550 is an inhibitor of MDMX that disrupts MDMX-p53 peptide interaction with an EC50 value of 4.3 µM.1 It forms a covalent, but reversible, cysteine adduct in the MDMX p53-binding domain, locking MDMX into a conformation that prevents binding to p53.2 SJ 172550 induces apoptosis, increases p53 target gene expression, and causes p53-dependent cell death in retinoblastoma cells.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Reed, D.J., Shen, Y., Shelat, A.A., et al. Identification and characterization of the first small molecule inhibitor of MDMX. The Journal of Biological Chemisty 285(4), 10786-10796 (2010).

    2. Bista, M., Smithson, D., Pecak, A., et al. On the mechanism of action of SJ-172550 in inhibiting the interaction of MDM4 and p53. PLoS One 7(6), e37518 (2012).