An activator of mutant forms of p53
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COTI-2

Item No. 20031

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(2-pyridinyl)-2-(6,7-dihydro-8(5H)-quinolinylidene)hydrazide-1-piperazinecarbothioic acid
CAS Number
1039455-84-9
Molecular Formula
C19H22N6S
Formula Weight
366.5
Purity
≥95% (E/Z mixture)
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2.5 mg/mlDMF:PBS (pH 7.2) (1:4): 0.2 mg/mlDMSO: 1 mg/ml
SMILES
S=C(N/N=C1C(N=CC=C2)=C2CCC\1)N(CC3)CCN3C4=NC=CC=C4
InChi Code
InChI=1S/C19H22N6S/c26-19(23-22-16-7-3-5-15-6-4-10-21-18(15)16)25-13-11-24(12-14-25)17-8-1-2-9-20-17/h1-2,4,6,8-10H,3,5,7,11-14H2,(H,23,26)/b22-16-
InChi Key
UTDAKQMBNSHJJB-JWGURIENSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

    $128

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    10 mg

    $236

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    25 mg

    $502

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    Cayman Chemical
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    Product Description

    COTI-2 is an orally available thiosemicarbazone that activates mutant forms of p53. It induces apoptosis in a wide variety of human tumor cells in culture, inhibits the proliferation of colorectal cancer cell lines more effectively than cetuximab and erlotinib (Item No. 10483), and is active against human glioblastoma cell lines at nanomolar concentrations.1 COTI-2 functions well in vivo, inhibiting the growth of HT-29 colorectal, SHP-77 small cell lung cancer, and OVCAR-3 ovarian carcinoma xenograft cells in mice with minimal toxicity.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Salim, K.Y., Vareki, S.M., Danter, W.R., et al. COTI-2, a novel small molecule that is active against multiple human cancer cell lines in vitro and in vivo. Oncotarget 7(27), (2016).