The LTA hydrolase metabolite of LTA3
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Leukotriene B3

Item No. 20109

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5S,12R-dihydroxy-6Z,8E,10E-eicosatrienoic acid
CAS Number
88099-35-8
Synonyms
  • LTB3
Molecular Formula
C20H34O4
Formula Weight
338.5
Purity
≥97%
Formulation (Request formulation change)
A 100 µg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: MiscibleDMSO: MiscibleEthanol: MisciblePBS pH 7.2: >1 mg/ml
λmax
270 nm
SMILES
O[C@@H](/C=C/C=C/C=C\[C@@H](O)CCCC(O)=O)CCCCCCCC
InChi Code
InChI=1S/C20H34O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h7-8,10-11,14-15,18-19,21-22H,2-6,9,12-13,16-17H2,1H3,(H,23,24)/b8-7+,14-10+,15-11-/t18-,19-/m1/s1
InChi Key
NGTXCORNXNELNU-CHHAPGPYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    25 µg

    $159

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    50 µg

    $302

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    100 µg

    $508

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    Product Description

    LTB3 is the LTA hydrolase metabolite of LTA3 in the leukotriene biosynthetic pathway. LTB3 and LTB4 are equipotent in their pro-inflammatory effects.1,2 However, LTB3 is five times less potent than LTB4 in eliciting chemotaxis of human neutrophils.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lee, T.H., Sethi, T., Crea, A.E.G., et al. Characterization of leukotriene B3: Comparison of its biological activities with leukotriene B4 and leukotriene B5 in complement receptor enhancement, lysozyme release and chemotaxis of human neutrophils. Clin. Sci. (Lond.) 74, 467-475 (1988).

    2. Shimazaki, T., Kobayashi, Y., Sato, F., et al. Some newly synthesized leukotriene B4 analogs inhibit LTB4-induced lysozyme release from rat polymorphonuclear leukocytes. Prostaglandins 39, 459-467 (1990).

    Product Citations

    Archambault, A.-S., Zaid, Y., Rakotoarivelo, V., et al. Lipid storm within the lungs of severe COVID-19 patients: Extensive levels of cyclooxygenase and lipoxygenase-derived inflammatory metabolites. medRxiv (2020).