An FGF inhibitor
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NSC 12

Item No. 20117

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β)-24,24,24-trifluoro-23-(trifluoromethyl)-21-norchol-5-ene-3,20,23-triol
CAS Number
102586-30-1
Synonyms
  • NSC 172285
Molecular Formula
C24H34F6O3
Formula Weight
484.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 0.1 mg/mlEthanol: 20 mg/mlEthanol:PBS (pH 7.2)(1:2): 0.1 mg/ml
SMILES
O[C@H](C1)CC[C@@]2(C)C1=CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])C(O)CC(O)(C(F)(F)F)C(F)(F)F
InChi Code
InChI=1S/C24H34F6O3/c1-20-9-7-14(31)11-13(20)3-4-15-16-5-6-18(21(16,2)10-8-17(15)20)19(32)12-22(33,23(25,26)27)24(28,29)30/h3,14-19,31-33H,4-12H2,1-2H3/t14-,15-,16-,17-,18+,19?,20-,21-/m0/s1
InChi Key
OHKBOEWLASAFLW-STFFYOTPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    NSC 12 is an extracellular trap for fibroblast growth factor 2 (FGF2) that binds FGF2 (Kd = 51 µM) and interferes with its interaction with FGFR1, without affecting the ability of FGF2 to bind heparin or heparin sulfate proteoglycans (HSPGs).1 NSC 12 also binds several other, but not all, FGF isoforms with Kd values ranging between 16 and 120 µM, preventing them from forming HSPG/FGF/FGFR ternary complexes.1 NSC 12 inhibits FGF-dependent angiogenesis and tumor cell proliferation in vitro and reduces tumor growth in mice.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. ROnca, R., Giacomini, A., Di Salle, E., et al. Long-pentraxin 3 derivative as a small-molecule FGF trap for cancer therapy. Cancer Cell 28(2), 225-238 (2015).