An L-type Ca2+ channel agonist
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

FPL 64176

Item No. 20122

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,5-dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylic acid, methyl ester
CAS Number
120934-96-5
Molecular Formula
C22H21NO3
Formula Weight
347.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mLDMSO: 25 mg/mLDMSO:PBS(pH 7.2) (1:4): 0.2 mg/mLEthanol: 2 mg/mL
λmax
294 nm
SMILES
O=C(C1=C(C)NC(C)=C1C(OC)=O)C2=CC=CC=C2CC3=CC=CC=C3
InChi Code
InChI=1S/C22H21NO3/c1-14-19(20(15(2)23-14)22(25)26-3)21(24)18-12-8-7-11-17(18)13-16-9-5-4-6-10-16/h4-12,23H,13H2,1-3H3
InChi Key
MDMWHKZANMNXTF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $36

    Add

    5 mg

    $77

    Add

    10 mg

    $135

    Add
    Product Description

    FPL 64176 is a nondihydropyridine that activates L-type Ca2+ channels with an EC50 value of 16 nM.1,2 It prolongs action potential duration and increases contractility in guinea pig atria preparations with an EC50 value of 49 nM.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zheng, W., Rampe, D., and Triggle, D.J. Pharmacological, radioligand binding, and electrophysiological characteristics of FPL 64176, a novel nondihydropyridine Ca2+ channel activator, in cardiac and vascular preparations. Mol. Pharmacol. 40(5), 734-741 (1991).

    2. Baxter, A.J.G., Dixon, J., Ince, F., et al. Discovery and synthesis of methyl 2,5-dimethyl-4-[2- (phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylate (FPL 64176) and analogues: The first examples of a new class of calcium channel activator. J. Med. Chem. 36(19), 2739-2744 (1993).

    3. Rampe, D., Anderson, B., Rapien-Pryor, V., et al. Comparison of the in vitro and in vivo cardiovascular effects of two structurally distinct Ca++ channel activators, BAY K 8644 and FPL 64176. J. Pharmacol. Exp. Ther. 265(3), 1125-1130 (1993).