An L-type Ca2+ channel agonist
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FPL 64176

Item No. 20122

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,5-dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylic acid, methyl ester
CAS Number
120934-96-5
Molecular Formula
C22H21NO3
Formula Weight
347.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mLDMSO: 25 mg/mLDMSO:PBS(pH 7.2) (1:4): 0.2 mg/mLEthanol: 2 mg/mL
λmax
294 nm
SMILES
O=C(C1=C(C)NC(C)=C1C(OC)=O)C2=CC=CC=C2CC3=CC=CC=C3
InChi Code
InChI=1S/C22H21NO3/c1-14-19(20(15(2)23-14)22(25)26-3)21(24)18-12-8-7-11-17(18)13-16-9-5-4-6-10-16/h4-12,23H,13H2,1-3H3
InChi Key
MDMWHKZANMNXTF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $77

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    10 mg

    $135

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    Product Description

    FPL 64176 is a nondihydropyridine that activates L-type Ca2+ channels with an EC50 value of 16 nM.1,2 It prolongs action potential duration and increases contractility in guinea pig atria preparations with an EC50 value of 49 nM.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zheng, W., Rampe, D., and Triggle, D.J. Pharmacological, radioligand binding, and electrophysiological characteristics of FPL 64176, a novel nondihydropyridine Ca2+ channel activator, in cardiac and vascular preparations. Mol. Pharmacol. 40(5), 734-741 (1991).

    2. Baxter, A.J.G., Dixon, J., Ince, F., et al. Discovery and synthesis of methyl 2,5-dimethyl-4-[2- (phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylate (FPL 64176) and analogues: The first examples of a new class of calcium channel activator. J. Med. Chem. 36(19), 2739-2744 (1993).

    3. Rampe, D., Anderson, B., Rapien-Pryor, V., et al. Comparison of the in vitro and in vivo cardiovascular effects of two structurally distinct Ca++ channel activators, BAY K 8644 and FPL 64176. J. Pharmacol. Exp. Ther. 265(3), 1125-1130 (1993).