A potent and selective PDE11 inhibitor
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BC-11-38

Item No. 20167

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6,7-dihydro-3-phenyl-2-(propylthio)-thieno[3,2-d]pyrimidin-4(3H)-one
CAS Number
686770-80-9
Molecular Formula
C15H16N2OS2
Formula Weight
304.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mLDMSO: 30 mg/mLDMSO:PBS (pH 7.2) (1:2): 0.33 mg/mLEthanol: 5 mg/mL
λmax
264, 343 nm
SMILES
O=C1C2=C(CCS2)N=C(SCCC)N1C3=CC=CC=C3
InChi Code
InChI=1S/C15H16N2OS2/c1-2-9-20-15-16-12-8-10-19-13(12)14(18)17(15)11-6-4-3-5-7-11/h3-7H,2,8-10H2,1H3
InChi Key
YHNDCCKFNWDQGW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $75

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    10 mg

    $120

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    25 mg

    $278

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    Product Description

    BC-11-38 is a potent and selective phosphodiesterase (PDE) 11 inhibitor (IC50s = 0.28 µM and >100 µM for PDE11 and PDE1-10, respectively).1 Gene association studies suggested that PDE11 was involved in adrenal function, and in H295R human adrenocortical cells, BC-11-38 increased cAMP and cortisol levels and activating transcription factor 1 (ATF-1) phosphorylation.2,3,1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ceyhan, O., Birsoy, K., and Hoffman, C.S. Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen. Chem. Biol. 19(1), 155-163 (2012).

    2. Horvath, A., Giatzakis, C., Robinson-White, A., et al. Adrenal hyperplasia and adenomas are associated with inhibition of phosphodiesterase 11A in carriers of PDE11A sequence variants that are frequent in the population. Cancer Res. 66(24), 11571-11575 (2006).

    3. Libé, R., Horvath, A., Cezzosi, D., et al. Frequent phosphodiesterase 11A gene (PDE11A) defects in patients with Carney complex (CNC) caused by PRKAR1A mutations: PDE11A may contribute to adrenal and testicular tumors in CNC as a modifier of the phenotype. J. Clin. Endocrinol. Metab. 96(1), E208-E214 (2011).