β-oxidation metabolite of LTB4
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18-carboxy dinor Leukotriene B4

Item No. 20170

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7R,14S-dihydroxy-4Z,8E,10E,12Z-octadecatetraenedioic acid
CAS Number
102674-12-4
Synonyms
  • 18-carboxy dinor LTB4
Molecular Formula
C18H26O6
Formula Weight
338.4
Purity
≥97%
Formulation (Request formulation change)
A 100 µg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 50 mg/mlEthanol: 50 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
270 nm
SMILES
O[C@@H](/C=C/C=C\C=C\[C@@H](O)CCCC(=O)O)C/C=C\CCC(=O)O
InChi Code
InChI=1S/C18H26O6/c19-15(11-6-3-7-13-17(21)22)9-4-1-2-5-10-16(20)12-8-14-18(23)24/h1-6,9-10,15-16,19-20H,7-8,11-14H2,(H,21,22)(H,23,24)/b2-1+,6-3-,9-4+,10-5-/t15-,16+/m0/s1
InChi Key
XWRIIHRGMKHPHN-USRRKILKSA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    25 µg

    $192

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    50 µg

    $361

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    100 µg

    $680

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    Product Description

    18-carboxy dinor Leukotriene B4 (18-carboxy dinor LTB4) is a β-oxidation metabolite of LTB4.1 In the liver, LTB4 is rapidly metabolized to 20-carboxy LTB4, which then undergoes β-oxidation to 18-carboxy dinor LTB4.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Harper, T.W., Garrity, M.J., and Murphy, R.C. Metabolism of leukotriene B4 in isolated rat hepatocytes. Identification of a novel 18-carboxy-19,20-dinor leukotriene B4 metabolite. The Journal of Biological Chemisty 261(12), 5414-5418 (1986).

    2. Shirley, M.A., and Murphy, R.C. Metabolism of leukotriene B4 in isolated rat hepatocytes. Involvement of 2,4-dienoyl-coenzyme a reductase in leukotriene B4 metabolism. The Journal of Biological Chemisty 265, 16288-16295 (1990).