A neuroprotective agent
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PAQ

Item No. 20234

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-phenyl-6-quinoxalinamine
CAS Number
943902-10-1
Synonyms
  • 3-Phenyl-6-aminoquinoxaline
Molecular Formula
C14H11N3
Formula Weight
221.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 2 mg/ml
λmax
248, 282, 403 nm
SMILES
NC1=CC=C(N=CC(C2=CC=CC=C2)=N3)C3=C1
InChi Code
InChI=1S/C14H11N3/c15-11-6-7-12-13(8-11)17-14(9-16-12)10-4-2-1-3-5-10/h1-9H,15H2
InChi Key
BTTJRYBJJULOGN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $48

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    5 mg

    $206

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    10 mg

    $366

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    25 mg

    $796

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    Product Description

    PAQ is a neuroprotective agent.1 It protects dopaminergic neurons from cell death without inhibiting glial cell proliferation in a rat midbrain culture model of Parkinson’s disease when used at a concentration of 10 μM. PAQ (25 or 50 mg/kg, twice per day) prevents loss of dopaminergic neurons in the substantia nigra in a mouse model of Parkinson’s disease induced by MPTP.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Le Douaron, G., Ferrié, L., Sepulveda-Diaz, J.E., et al. New 6-aminoquinoxaline derivatives with neuroprotective effect on dopaminergic neurons in cellular and animal parkinson disease models. J. Med. Chem. 59(13), 6169-6186 (2016).