A PLA2 inhibitor
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ONO-RS-082

Item No. 20243

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-chloro-2-[[(2E)-1-oxo-3-(4-pentylphenyl)-2-propen-1-yl]amino]-benzoic acid
CAS Number
99754-06-0
Molecular Formula
C21H22ClNO3
Formula Weight
371.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 33 mg/mlDMSO: 33 mg/mlDMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
λmax
223, 251, 301, 321 nm
SMILES
ClC1=CC(NC(/C=C/C2=CC=C(CCCCC)C=C2)=O)=C(C(O)=O)C=C1
InChi Code
InChI=1S/C21H22ClNO3/c1-2-3-4-5-15-6-8-16(9-7-15)10-13-20(24)23-19-14-17(22)11-12-18(19)21(25)26/h6-14H,2-5H2,1H3,(H,23,24)(H,25,26)/b13-10+
InChi Key
MDVFITMPFHDRBZ-JLHYYAGUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $143

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    100 mg

    $268

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    Product Description

    ONO-RS-082 is a reversible inhibitor of Ca2+-independent phospholipase A2.1 At 3.5 µM, it has been shown to inhibit epinephrine-stimulated thromboxane production in human platelets.1 ONO-RS-082 can also disrupt endosome tubule formation and maintenance of the Golgi complex.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Banga, H.S., Simons, E.R., Brass, L.F., et al. Activation of phospholipases A and C in human platelets exposed to epinephrine: Role of glycoproteins IIb/IIIa and dual role of epinephrine. Proc. Natl. Acad. Sci. USA 83(23), 9197-9201 (1986).

    2. de Figueiredo, P., Doody, A., Polizotto, R.S., et al. Inhibition of transferrin recycling and endosome tubulation by phospholipase A2 antagonists. The Journal of Biological Chemisty 276(50), 47361-47370 (2001).

    3. Bechler, M.E., and Brown, W.J. Gβ1γ2 activates phospholipase A2-dependent Golgi membrane tubule formation. Front. Cell. Dev. Biol. 2(4), (2014).