A metabolite of vitamin B1
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Product Categories

Product Type

Biochemicals

Research Area

Endocrinology & Metabolism
Cofactors & Vitamins

Thiamine Pyrophosphate (chloride)

Item No. 20254

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-4-methyl-5-(4,6,6-trihydroxy-4,6-dioxido-3,5-dioxa-4,6-diphosphahex-1-yl)-thiazolium, monochloride
CAS Number
154-87-0
Synonyms
  • Cocarboxylase
  • TPP
  • Vitamin B1 Pyrophosphate
Molecular Formula
C12H19N4O7P2S • Cl
Formula Weight
460.8
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: InsolDMSO: InsolEthanol: InsolPBS (pH 7.2): 10 mg/mL
λmax
246 nm
SMILES
CC1=NC(N)=C(C[N+]2=CSC(CCOP(OP(O)(O)=O)(O)=O)=C2C)C=N1.[Cl-]
InChi Code
InChI=1S/C12H18N4O7P2S.ClH/c1-8-11(3-4-22-25(20,21)23-24(17,18)19)26-7-16(8)6-10-5-14-9(2)15-12(10)13;/h5,7H,3-4,6H2,1-2H3,(H4-,13,14,15,17,18,19,20,21);1H
InChi Key
YXVCLPJQTZXJLH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

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    1 g

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    Product Description

    Thiamine pyrophosphate (TPP) (chloride) is a metabolite of vitamin B1. It is a cofactor synthesized in the cytosol that is required for the activity of cytosolic transketolase and mitochondrial pyruvate, oxoglutarate, and branched-chain keto acid dehydrogenases.1 TPP (chloride) prevents hyperglycemia-induced retinopathy and desflurane-induced hepatotoxicity in rats.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hawkins, C.F., Borges, A., and Perham, R.N. A common structural motif in thiamin pyrophosphate-binding enzymes. FEBS Lett. 255(1), 77-82 (1989).

    2. Cinici, E., Ahiskali, I., Cetin, N., et al. Effect of thiamine pyrophosphate on retinopathy induced by hyperglycemia in rats: A biochemical and pathological evaluation. Indian J. Ophthalmol. 64(6), 434-439 (2016).

    3. Arslan, A., Kuyrukluyildiz, U., Binici, O., et al. Can thiamine pyrophosphate prevent desflurane induced hepatotoxicity in rats? Acta Cir. Bras. 31(3), 168-175 (2016).