A natural kavalactone
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Analytical Standard(s)
33882Methysticin 41195Methysticin (CRM)
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Methysticin

Item No. 20258

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(6R)-6-[(1E)-2-(1,3-benzodioxol-5-yl)ethenyl]-5,6-dihydro-4-methoxy-2H-pyran-2-one
CAS Number
495-85-2
Synonyms
  • Kavatin
  • (+)-Methysticin
  • NSC 112158
Molecular Formula
C15H14O5
Formula Weight
274.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mLDMSO: 5 mg/mLDMSO:PBS (pH 7.2) (1:6): 0.1 mg/mLEthanol: 1 mg/mL
λmax
208, 225, 265, 306 nm
SMILES
COC(C[C@H](/C=C/C1=CC=C(OCO2)C2=C1)O3)=CC3=O
InChi Code
InChI=1S/C15H14O5/c1-17-12-7-11(20-15(16)8-12)4-2-10-3-5-13-14(6-10)19-9-18-13/h2-6,8,11H,7,9H2,1H3/b4-2+/t11-/m0/s1
InChi Key
GTEXBOVBADJOQH-FWEMWIAWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    1 mg

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    5 mg

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    Product Description

    Methysticin is a natural kavalactone from the kava plant, P. methysticum. It enhances the binding of bicuculline methochloride at the γ-aminobutyric acid (GABA) receptor GABAA at 0.1 µM.1 Methysticin inhibits the cytochrome P450 (CYP) isoforms CYP2C9 and CYP2D6.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Boonen, G., and Häberlein, H. Influence of genuine kavapyrone enantiomers on the GABAA binding site. Planta Med. 64(6), 504-506 (1998).

    2. Murray, M. Toxicological actions of plant-derived and anthropogenic methylenedioxyphenyl-substituted chemicals in mammals and insects. J. Toxicol. Environ. Health B Crit. Rev. 15(6), 365-395 (2012).