A selective androgen receptor modulator
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GSK2881078

Item No. 20313

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[(1R)-1-methyl-2-(methylsulfonyl)ethyl]-4-(trifluoromethyl)-1H-indole-5-carbonitrile
CAS Number
1539314-06-1
Molecular Formula
C14H13F3N2O2S
Formula Weight
330.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlDMSO:PBS (pH 7.2) (1:6): 0.14 mg/mlEthanol: 20 mg/ml
λmax
243, 303 nm
SMILES
CS(C[C@@H](C)N1C2=CC=C(C#N)C(C(F)(F)F)=C2C=C1)(=O)=O
InChi Code
InChI=1S/C14H13F3N2O2S/c1-9(8-22(2,20)21)19-6-5-11-12(19)4-3-10(7-18)13(11)14(15,16)17/h3-6,9H,8H2,1-2H3/t9-/m1/s1
InChi Key
SKDVMPZQJMZEAC-SECBINFHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $42

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    5 mg

    $183

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    10 mg

    $322

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    25 mg

    $702

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    Product Description

    GSK2881078 is a selective androgen receptor modulator (SARM).1 It induces AR-mediated transcriptional activation in PC3(AR)2 cells (EC50 = 3.99 nM), an effect that can be inhibited by the non-steroidal AR antagonist bicalutamide (Item No. 14250).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zierau, O., Kolodziejczyk, A., Vollmer, G., et al. Comparison of the three SARMs RAD-140, GLPG0492 and GSK-2881078 in two different in vitro bioassays, and in an in silico androgen receptor binding assay. J. Steroid Biochem. Mol. Biol. 189, 81-86 (2019).