A potent fluoroquinolone antibiotic
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Delafloxacin

Item No. 20314

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(6-amino-3,5-difluoro-2-pyridinyl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-hydroxy-1-azetidinyl)-4-oxo-3-quinolinecarboxylic acid
CAS Number
189279-58-1
Synonyms
  • ABT-492
  • RX-3341
Molecular Formula
C18H12ClF3N4O4
Formula Weight
440.8
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 0.5 mg/ml
λmax
228, 288, 334 nm
SMILES
ClC1=C(N2CC(O)C2)C(F)=CC3=C1N(C4=C(F)C=C(F)C(N)=N4)C=C(C(O)=O)C3=O
InChi Code
InChI=1S/C18H12ClF3N4O4/c19-12-13-7(1-9(20)14(12)25-3-6(27)4-25)15(28)8(18(29)30)5-26(13)17-11(22)2-10(21)16(23)24-17/h1-2,5-6,27H,3-4H2,(H2,23,24)(H,29,30)
InChi Key
DYDCPNMLZGFQTM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Cayman Chemical
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    Product Description

    Delafloxacin is a fluoroquinolone antibiotic that demonstrates extremely high potency against a wide range of bacteria in vitro, including levofloxacin-resistant strains of S. pneumoniae and methicillin-resistant S. aureus.1,2 It targets both DNA gyrase and topoisomerase IV. Delafloxacin has an anionic structure, which enhances its potency in acidic environments (e.g., phagolysosome, inflammatory cells) and in skin and soft tissue infections.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Goldstein, E.J.C., Citron, D.M., Merriam, C.V., et al. In vitro activities of ABT-492, a new fluoroquinolone, against 155 aerobic and 171 anaerobic pathogens isolated from antral sinus puncture specimens from patients with sinusitis. Antimicrob. Agents Chemother. 47(9), 3008-3011 (2003).

    2. Nilius, A.M., Shen, L.L., Hensey-Rudloff, D., et al. In vitro antibacterial potency and spectrum of ABT-492, a new fluoroquinolone. Antimicrob. Agents Chemother. 47(10), 3260-3269 (2003).

    3. Kocsis, B., Domokos, J., and Szabo, D. Chemical structure and pharmacokinetics of novel quinolone agents represented by avarofloxacin, delafloxacin, finafloxacin, zabofloxacin and nemonoxacin. Ann. Clin. Microbiol. Antimicrob. 15(1), 34 (2016).