MMP-2/MMP-9 Inhibitor I

MMP-2/MMP-9 inhibitor I is a potent inhibitor of matrix metalloproteinase-2 (MMP-2) and MMP-9 (IC₅₀s = 310 and 240 nM, respectively).¹ It acts by binding zinc at the active site of these MMPs. MMP-2/MMP-9 inhibitor I is active in vivo as well as in vitro and blocks MMP-2/MMP-9-dependent invasion, tumor growth, and metastasis in both cell culture and mouse tumor models.¹ This compound has been used to elucidate the roles of MMP-2 and MMP-9 in diverse systems, including mammary epithelial cell transformation, neuronal dysfunction, lymphocyte recruitment, and progressive hereditary kidney disease.^2,3,4,5

WARNING This product is not for human or veterinary use.

1. Tamura, Y., Watamane, F., Nakatani, T., et al. Highly selective and orally active inhibitors of type IV collagenase (MMP-9 and MMP-2): N-sulfonylamino acid derivatives. J. Med. Chem. 41(4), 640-649 (1998).

2. Dechow, T.B., Pedranzini, L., Leitch, A., et al. Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C. Proc. Natl. Acad. Sci. USA 101(29), 10602-10607 (2004).

3. Lim, K., Hyun, Y.-M., Lambert-Emo, K., et al. Neutrophil trails guide influenza-specific CD8⁺ T cells in the airways. Science 349(6252), (2015).

4. Mizoguchi, H., Yamada, K., and Nabeshima, T. Matrix metalloproteinases contribute to neuronal dysfunction in animal models of drug dependence, Alzheimer’s disease, and epilepsy. 2011:681385, (2011).

5. Zeisberg, M., Khurana, M., Rao, V.H., et al. Stage-specific action of matrix metalloproteinases influences progressive hereditary kidney disease. PLoS Med. 3(4), (2006).