A brassinosteroid with protective effects
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Epibrassinolide

Item No. 20337

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1R,3aS,3bS,6aS,8S,9R,10aR,10bS,12aS)-12a-dimethyl-1-[(1S,2R,3R,4R)-2,3-dihydroxy-1,4,5-trimethylhexyl]hexadecahydro-8,9-dihydroxy-10a6H-benz[c]indeno[5,4-e]oxepin-6-one
CAS Number
78821-43-9
Synonyms
  • EBL
  • 24-Epibrassinolide
Molecular Formula
C28H48O6
Formula Weight
480.7
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMF:PBS (pH 7.2) (1:3): 0.25 mg/mlDMSO: 3 mg/mlEthanol: 3 mg/ml
SMILES
O=C1[C@]2([H])[C@@](C[C@@H](O)[C@@H](O)C2)(C)[C@@]3([H])CC[C@@]4(C)[C@](CC[C@]4([H])[C@H](C)[C@@H](O)[C@H](O)[C@H](C)C(C)C)([H])[C@]3([H])CO1
InChi Code
InChI=1S/C28H48O6/c1-14(2)15(3)24(31)25(32)16(4)18-7-8-19-17-13-34-26(33)21-11-22(29)23(30)12-28(21,6)20(17)9-10-27(18,19)5/h14-25,29-32H,7-13H2,1-6H3/t15-,16+,17+,18-,19+,20+,21-,22+,23-,24-,25-,27-,28-/m1/s1
InChi Key
IXVMHGVQKLDRKH-QHBHMFGVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $75

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    5 mg

    $295

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    10 mg

    $442

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    25 mg

    $827

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    Cayman Chemical
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    Product Description

    Epibrassinolide is a brassinosteroid that can be isolated from various plants and has been shown to decrease toxicity and stimulate healthy plant growth in plants under stress.1 Epibrassinolide is also reported to be a potential apoptotic inducer in various cancer cells without affecting the non-tumor cell growth.2 It has also been shown to protect neuronal PC12 cells from 1-methyl-4-phenylpyridinium-induced oxidative stress and consequent apoptosis in dopaminergic neurons.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sondhi, N., Bhardwaj, R., Kaur, S., et al. Isolation of 24-epibrassinolide from leaves of Aegle marmelos and evaluation of its antigenotoxicity employing Allium cepa chromosomal aberration assay. Plant Growth Regul. 54(3), 217-224 (2008).

    2. Obakan, P., Barrero, C., Coker-Gurkan, A., et al. SILAC-based mass pectrometry analysis reveals that epibrassinolide induces apoptosis via activating endoplasmic reticulum stress in prostate cancer cells. PLoS One 10(9), (2015).

    3. Carange, J., Longpré, F., Daoust, B., et al. 24-Epibrassinolide, a phytosterol from the brassinosteroid family, protects dopaminergic cells against MPP-induced oxidative stress and apoptosis. J. Toxicol. 392859 (2011).