Triclosan

Triclosan is an antibiotic and antifungal.^1,2 It is an inhibitor of E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabI^G93V; IC₅₀s = 2 and 10 µM, respectively).¹ Triclosan is active against the bacteria M. epidermidis, M. lysodeikticus, S. aureus, S. lactis, and S. haemolyticus (MICs = 0.03, 0.01, 3, 3, and 1 µg/ml, respectively) and the fungi A. fumigatus, C. albicans, and C. tropicalis (MICs = 10 µg/ml for all).² It also decreases reattachment to dentin chips by, reduces the viability of, and increases lactate dehydrogenase (LDH) secretion from, human SG gingival epithelial cells when used at concentrations of 30, 100, and 500 µM, respectively.³

WARNING This product is not for human or veterinary use.

1. Heath, R.J., Rubin, J.R., Holland, D.R., et al. Mechanism of triclosan inhibition of bacterial fatty acid synthesis. The Journal of Biological Chemisty 274(16), 11110-11114 (1999).

2. Regös, J., Zak, O., Solf, R., et al. Antimicrobial spectrum of triclosan, a broad-spectrum antimicrobial agent for topical application. II. Comparison with some other antimicrobial agents. Dermatologica 158(1), 72-79 (1979).

3. Zuckerbraun, H.L., Babich, H., May, R., et al. Triclosan: Cytotoxicity, mode of action, and induction of apoptosis in human gingival cells in vitro. Eur. J. Oral Sci. 106(2 Pt 1), 628-636 (1998).