An activator of ERG1 and ERG2
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NS 1643

Item No. 20343

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N'-bis[2-hydroxy-5-(trifluoromethyl)phenyl]-urea
CAS Number
448895-37-2
Molecular Formula
C15H10F6N2O3
Formula Weight
380.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlDMSO:PBS(pH 7.2) (1:3): 0.25 mg/mlEthanol: 10 mg/ml
λmax
211, 240, 261, 292 nm
SMILES
OC1=C(C=C(C=C1)C(F)(F)F)NC(NC2=CC(C(F)(F)F)=CC=C2O)=O
InChi Code
InChI=1S/C15H10F6N2O3/c16-14(17,18)7-1-3-11(24)9(5-7)22-13(26)23-10-6-8(15(19,20)21)2-4-12(10)25/h1-6,24-25H,(H2,22,23,26)
InChi Key
NJFVQMRYJZHGME-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $49

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    10 mg

    $93

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    25 mg

    $190

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    50 mg

    $329

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    Product Description

    NS 1643 is an activator of the human ether-a-go-go related gene (ERG1, KCNH2, hERG) KV11.1 channel (EC50 = 10.5 μM).1,2 It also activates the KV11.2 (ERG2, KCNH6) channel, but evokes a distinctly different response from that of KV11.1.3 NS 1643 is commonly used in cells or isolated tissues.1,2,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Casis, O., Olesen, S.-P., and Sangunietti, M.C. Mechanism of action of a novel human ether-a-go-go-related gene channel activator. Mol. Pharmacol. 69(2), 658-665 (2006).

    2. Hansen, R.S., Diness, T.G., Christ, T., et al. Activation of human ether-a-go-go-related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643). Mol. Pharmacol. 69(1), 266-277 (2006).

    3. Elmedyb, P., Olesen, S.-P., and Grunnet, M. Activation of ERG2 potassium channels by the diphenylurea NS1643. Neuropharmacology 53(2), 283-294 (2007).

    4. Killeen, M.J., Thomas, G., Olesen, S.-P., et al. Effects of potassium channel openers in the isolated perfused hypokalaemic murine heart. Acta. Physiol. (Oxf) 193(1), 25-36 (2008).