An enzyme cofactor
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Pyridoxal 5'-phosphate (hydrate)

Item No. 20352

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]-4-pyridinecarboxaldehyde, hydrate
CAS Number
853645-22-4
Molecular Formula
C8H10NO6P • XH2O
Formula Weight
265.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 1 mg/ml
λmax
295, 388 nm
SMILES
CC1=C(O)C(C([H])=O)=C(COP(O)(O)=O)C=N1.O
InChi Code
InChI=1S/C8H10NO6P.H2O/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14;/h2-3,11H,4H2,1H3,(H2,12,13,14);1H2
InChi Key
CEEQUQSGVRRXQI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $49

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    5 g

    $167

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    10 g

    $283

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    25 g

    $587

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    Product Description

    Pyridoxal 5′-phosphate, the active form of vitamin B6, is a cofactor for many different enzymes involved in transamination reactions, including mitochondrial cysteine desulfurase, cystathionine γ-synthase, various aminotransferases, and d-serine dehydratase. It has been used to study the pyridoxal 5′-phosphate-dependent active sites of these enzymes.1,2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhu, W., Lin, A., and Banerjee, R. Kinetic properties of polymorphic variants and pathogenic mutants in human cystathionine γ-lyase. Biochemistry 47(23), 6226-6232 (2008).

    2. Steegborn, C., Clausen, T., Sondermann, P., et al. Kinetics and inhibition of recombinant human cystathionine γ-lyase. Toward the rational control of transsulfuration. The Journal of Biological Chemisty 274(18), 12675-12684 (1999).

    3. Goto, M., Miyahara, I., Hayashi, H., et al. Crystal structures of branched-chain amino acid aminotransferase complexed with glutamate and glutarate: True reaction intermediate and double substrate recognition of the enzyme. Biochem. 42(13), 3725-3733 (2003).

    4. Brosnan, J.T., and Brosnan, M.E. Branched-chain amino acids: Enzyme and substrate regulation. J. Nutr. 136(1), 207S-211S (2006).