Narciclasine

Narciclasine is an isocarbostyril alkaloid that has been found in Narcissus and has diverse biological activities.^1,2,3,4,5 It selectively induces apoptosis in PC3 prostate and MCF-7 and MDA-MB-231 breast cancer cells over CCD-25Lu fibroblasts at 1 µM.¹ Narciclasine has antiproliferative activity against a panel of six glioblastoma cancer cell lines (mean IC₅₀ = ~50 nM), induces actin stress fiber formation in U373 MG glioblastoma cells, and increases survival in an orthotopic Hs 683 glioblastoma mouse xenograft model.² It also inhibits neurite outgrowth in SH-SY5Y cells with a 10% effective concentration (EC₁₀) value of 4.44 nM and suppresses the proliferation of isolated human T cells (IC₅₀ = 14 nM).^3,4 Intradermal administration of narciclasine (2 mg/kg) decreases disease severity and prevents increases in spleen weight in a mouse model of psoriasis induced by imiquimod (Item No. 14956).⁵

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1. Dumont, P., Ingrassia, L., Rouzeau, S., et al. The Amaryllidaceae isocarbostyril narciclasine induces apoptosis by activation of the death receptor and/or mitochondrial pathways in cancer cells but not in normal fibroblasts. Neoplasia 9(9), 766-776 (2007).

2. Lefranc, F., Sauvage, S., Van Goietsenoven, G., et al. Narciclasine, a plant growth modulator, activates Rho and stress fibers in glioblastoma cells. Mol. Cancer Ther. 8(7), 1739-1750 (2009).

3. Braun, G., Herberth, G., Krauss, M., et al. Neurotoxic mixture effects of chemicals extracted from blood of pregnant women. Science 386(6719), 301-309 (2024).

4. Wang, W.-L., Wu, X.-Y., Luo, X.-Y., et al. Immunosuppressive alkaloids from Narcissus tazetta subsp. Chinensis and the mechanism of (+)-narciclasine in vitro and in vivo. Phytochemistry 225:114198, (2024).

5. Kong, Y., Jiang, J., Huang, Y., et al. Narciclasine inhibits phospholipase A₂ and regulates phospholipid metabolism to ameliorate psoriasis-like dermatitis. Front. Immunol. 13:1094375, (2023).