An Analytical Reference Standard
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Active Metabolite(s)
9001921Difenoxin (hydrochloride)
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Diphenoxylate (hydrochloride)

Item No. 20374

Restricted Product (Schedule II)
Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • R 1132
Technical Information
Formal Name
1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-4-piperidinecarboxylic acid, ethyl ester, monohydrochloride
CAS Number
3810-80-8
Molecular Formula
C30H32N2O2 • HCl
Formula Weight
489.1
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/ml
SMILES
O=C(OCC)C1(C2=CC=CC=C2)CCN(CCC(C3=CC=CC=C3)(C#N)C4=CC=CC=C4)CC1.Cl
InChi Code
InChI=1S/C30H32N2O2.ClH/c1-2-34-28(33)29(25-12-6-3-7-13-25)18-21-32(22-19-29)23-20-30(24-31,26-14-8-4-9-15-26)27-16-10-5-11-17-27;/h3-17H,2,18-23H2,1H3;1H
InChi Key
SHTAFWKOISOCBI-UHFFFAOYSA-N
Regulatory Information
DEA Schedule
II
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Diphenoxylate (hydrochloride) (Item No. 20374) is an analytical reference standard categorized as an opioid.1 Diphenoxylate has been detected in products marketed as traditional herbal medicine and has been associated with abuse.2,3 Formulations containing diphenoxylate have been used in the treatment of diarrhea. Diphenoxylate is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bonifazi, A., Battiti, F.O., Sanchez, J., et al. Novel dual-target μ-opioid receptor and dopamine D3 receptor ligands as potential nonaddictive pharmacotherapeutics for pain management. J. Med. Chem. 64(11), 7778-7808 (2021).

    2. Foroughi, M.H., Akhgari, M., Jokar, F., et al. Identification of undeclared active pharmaceutical ingredients in counterfeit herbal medicines used as opioid substitution therapy. Aus. J. Forensic Sci. 49(6), 720-729 (2016).

    3. Mehra, A., Sarkar, S., and Basu, D. Lomotil (diphenoxylate) dependence in India. Indian J. Psychol. Med. 35(3), 248-250 (2013).