A fundamental component of glucose metabolism
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Product Categories

Product Type

Biochemicals

Research Area

Endocrinology & Metabolism
Carbohydrate Metabolism

D-Glucose-6-phosphate (sodium salt)

Item No. 20376

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
D-glucose-6-(dihydrogen phosphate), monosodium salt
CAS Number
54010-71-8
Synonyms
  • G6P
  • Sodium Glucose-6-phosphate
Molecular Formula
C6H12O9P • Na
Formula Weight
282.1
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
SMILES
O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)COP(O)([O-])=O.[Na+]
InChi Code
InChI=1S/C6H13O9P.Na/c7-1-3(8)5(10)6(11)4(9)2-15-16(12,13)14;/h1,3-6,8-11H,2H2,(H2,12,13,14);/q;+1/p-1/t3-,4+,5+,6+;/m0./s1
InChi Key
OBHLNVXMRZXIII-BTVCFUMJSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

    $36

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    1 g

    $68

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    5 g

    $236

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    Product Description

    D-Glucose-6-phosphate is formed in cells when glucose is phosphorylated by hexokinase (or glucokinase) or by the conversion of glucose-1-phosphate by phosphoglucomutase, which is the first step of glycogen synthesis.1 It is stored as glycogen when blood glucose levels are high. Disruption of D-glucose-6-phosphate activity leads to glycogen storage disease type I or von Gierke’s disease, a group of inherited metabolic diseases characterized by severe hypoglycemia, growth retardation, and hepatomegaly, due to accumulation of glycogen and fat in the liver.2,3 D-Glucose-6-phosphate is also the starting molecule of both glycolysis and the pentose phosphate pathways.4 Because cancer cells adopt glycolysis as a major source of metabolic energy production, and the pentose phosphate pathway plays a role in helping glycolytic cancer cells to meet their anabolic demands, this compound can be used to study the progression of this process.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Berg, J.M., Tymoczko, J.L., and Stryer, L. Section 25.5 NAD+, FAD, and coenzyme A are formed from ATP. Biochemistry 5th edition, (2002).

    2. Cappellini, M.D., and Fiorelli, G. Glucose-6-phosphate dehydrogenase deficiency. Lancet 371(9606), 64-74 (2008).

    3. Beutler, E. Glucose-6-phosphate dehydrogenase deficiency: A historical perspective. Blood 111(1), 16-24 (2008).

    4. Gumaa, K.A., and McLean, P. The pentose phosphate pathway of glucose metabolism: Enzyme profiles and transient and steady-state content of intermediates of alternative pathways of glucose metabolism in Krebs ascites cells. Biochem. J. 115(5), 1009-1029 (1969).

    5. Patra, K.C., and Hay, N. The pentose phosphate pathway and cancer. Trends Biochem. Sci. 39(8), 347-354 (2014).