An inhibitor of mycolic acid synthesis
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Isoniazid

Item No. 20378

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-pyridinecarboxylic acid, hydrazide
CAS Number
54-85-3
Synonyms
  • Isonicotinylhydrazide
  • NSC 9659
Molecular Formula
C6H7N3O
Formula Weight
137.1
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.5 mg/mLDMSO: 1 mg/mLEthanol: 0.30 mg/mLPBS (pH 7.2): 1 mg/mL
λmax
263 nm
SMILES
O=C(NN)C1=CC=NC=C1
InChi Code
InChI=1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)
InChi Key
QRXWMOHMRWLFEY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
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    50 g

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    Cayman Chemical
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    Product Description

    Isoniazid is an antibiotic that acts as a prodrug, being converted by bacterial catalase-peroxidases to form isonicotinic acyl-NADH complex, which inhibits mycolic acid biosynthesis.1 It is effective against several species of Mycobacterium, including M. tuberculosis.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, F., Langley, R., Gulten, R., et al. Mechanism of thioamide drug action against tuberculosis and leprosy. J. Exp. Med. 204(1), 72-78 (2007).

    2. Phetsuksiri, B., Baulard, A.R., Cooper, A.M., et al. Antimycobacterial activities of isoxyl and new derivatives through the inhibition of mycolic acid synthesis. Antimicrob. Agents Chemother. 43(5), 1042-1051 (1999).

    3. Chang, K.C., Yew, W.W., Tam, C.M., et al. WHO group 5 drugs and difficult multidrug-resistant tuberculosis: A systematic review with cohort analysis and meta-analysis. Antimicrob. Agents Chemother. 57(9), 4097-4104 (2013).