A prodrug for an active glucocorticoid
Related Products
Active Metabolite(s)
2031621-desacetyl Deflazacort
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Deflazacort

Item No. 20386

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
21-(acetyloxy)-11β-hydroxy-2'-methyl-5'H-pregna-1,4-dieno[17,16β-d]oxazole-3,20-dione
CAS Number
14484-47-0
Synonyms
  • DL-458IT
  • L-5,458
  • MDL 458
Molecular Formula
C25H31NO6
Formula Weight
441.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS(pH 7.2) (1:3): 0.25 mg/mlEthanol: 1 mg/ml
λmax
242 nm
SMILES
O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@]5([H])[C@@]4(C(COC(C)=O)=O)N=C(C)O5)=C1
InChi Code
InChI=1S/C25H31NO6/c1-13-26-25(20(30)12-31-14(2)27)21(32-13)10-18-17-6-5-15-9-16(28)7-8-23(15,3)22(17)19(29)11-24(18,25)4/h7-9,17-19,21-22,29H,5-6,10-12H2,1-4H3/t17-,18-,19-,21+,22+,23-,24-,25+/m0/s1
InChi Key
FBHSPRKOSMHSIF-GRMWVWQJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    25 mg

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    50 mg

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    100 mg

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    250 mg

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    Product Description

    Deflazacort is a prodrug for the active glucocorticoid 21-desacetyl deflazacort (Item No. 20316). Deflazacort and related glucocorticoids have anti-inflammatory and immunosuppressant effects, as well as benefits in certain muscular dystrophies.1,2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Canonica, G.W., Ciprandi, G., Passalacqua, G., et al. Molecular events in allergic inflammation: Experimental models and possible modulation. Allergy 52(suppl 34), 25-30 (1997).

    2. Czaja, A.J. Promising pharmacological, molecular and cellular treatments of autoimmune hepatitis. Curr. Pharm. Des. 17(29), 3120-3140 (2011).

    3. Matthews, E., Brassington, R., Kuntzer, T., et al. Corticosteroids for the treatment of Duchenne muscular dystrophy. Cochrane Database Syst. Rev. 5, CD003725 (2016).