A prodrug form of thiorphan
Related Products
Active Metabolite(s)
15600Thiorphan
Labeled Version(s)
33893Racecadotril-d5
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Racecadotril

Item No. 20390

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-[(acetylthio)methyl]-1-oxo-3-phenylpropyl]-glycine, phenylmethyl ester
CAS Number
81110-73-8
Synonyms
  • Acetorphan
Molecular Formula
C21H23NO4S
Formula Weight
385.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:6): 0.16 mg/mlEthanol: 10 mg/ml
SMILES
O=C(NCC(OCC1=CC=CC=C1)=O)C(CSC(C)=O)CC2=CC=CC=C2
InChi Code
InChI=1S/C21H23NO4S/c1-16(23)27-15-19(12-17-8-4-2-5-9-17)21(25)22-13-20(24)26-14-18-10-6-3-7-11-18/h2-11,19H,12-15H2,1H3,(H,22,25)
InChi Key
ODUOJXZPIYUATO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    100 mg

    $36

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    250 mg

    $77

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    500 mg

    $110

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    1 g

    $135

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    Product Description

    Racecadotril is a prodrug form of the neprilysin (NEP) inhibitor thiorphan (Item No. 15600).1,2 In vivo, racecadotril reduces or prevents castor oil-induced diarrhea without delaying intestinal transit in rats when administered at doses of 80 or 100 mg/kg, respectively.1 It also decreases the duration of diarrhea and increases body weight gain in a neonatal gnotobiotic pig model of human rotavirus-induced diarrhea.2 Formulations containing racecadotril have been used in the treatment of acute diarrhea.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Griggs, D.W., Prinsen, M.J., Oliva, J., et al. Pharmacologic comparison of clinical neutral endopeptidase inhibitors in a rat model of acute secretory diarrhea. J. Pharmacol. Exp. Ther. 357(2), 423-431 (2016).

    2. Bui, T., Li, G., Kim, I., et al. Effects of racecadotril on weight loss and diarrhea due to human rotavirus in neonatal gnotobiotic pigs (Sus scrofa domesticus). Comp. Med. 67(2), 157-164 (2017).