A selective PTP1B inhibitor
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Product Categories

Product Type

Small Molecule Modulators
Small Molecule Inhibitors
Phosphatases

Research Area

TCS 401

Item No. 20393

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(carboxycarbonyl)amino]-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine-3-carboxylic acid, monohydrochloride
CAS Number
243966-09-8
Molecular Formula
C10H10N2O5S • HCl
Formula Weight
306.7
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
0.1 M NaOH: 5 mg/ml
SMILES
OC(C1=C(NC(C(O)=O)=O)SC2=C1CCNC2)=O.Cl
InChi Code
InChI=1S/C10H10N2O5S.ClH/c13-7(10(16)17)12-8-6(9(14)15)4-1-2-11-3-5(4)18-8;/h11H,1-3H2,(H,12,13)(H,14,15)(H,16,17);1H
InChi Key
LQGCAMWQDSYOAY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $37

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    5 mg

    $142

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    10 mg

    $246

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    25 mg

    $523

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    Product Description

    TCS 401 is a selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B; Ki = 0.29 µM).1 It inhibits the protein phosphatases CD45 D1D2, PTPβ, PTPε D1, SHP-1, PTPα D1, and LAR D1D2 at much higher concentrations (Kis = 59, 560, 1,100, >2,000, >2,000, and >2,000 μM, respectively).1 Several PTPs have been proposed to act as negative regulators of insulin signaling, thus this enzyme is a potential drug target in diabetes.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Iversen, L.F., Andersen, H.S., Branner, S., et al. Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B. The Journal of Biological Chemisty 275(14), 10300-10307 (2000).