A cell-permeant precursor of EGTA
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EGTA AM

Item No. 20401

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,12-bis[2-[(acetyloxy)methoxy]-2-oxoethyl]-6,9-dioxa-3,12-diazatetradecanedioic acid, 1,14-bis[(acetyloxy)methyl] ester
CAS Number
99590-86-0
Synonyms
  • EGTA Acetoxymethyl ester
Molecular Formula
C26H40N2O18
Formula Weight
668.6
Purity
≥90%
Formulation (Request formulation change)
A neat oil
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
CC(OCOC(CN(CC(OCOC(C)=O)=O)CCOCCOCCN(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O)=O)=O
InChi Code
InChI=1S/C26H40N2O18/c1-19(29)39-15-43-23(33)11-27(12-24(34)44-16-40-20(2)30)5-7-37-9-10-38-8-6-28(13-25(35)45-17-41-21(3)31)14-26(36)46-18-42-22(4)32/h5-18H2,1-4H3
InChi Key
GNJXVFXIDHCCKR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $329

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    Product Description

    EGTA AM is a cell-permeant acetoxymethyl ester of the calcium chelator EGTA. As EGTA AM enters cells, it is hydrolyzed by intracellular esterases to produce EGTA. EGTA AM is used to evaluate the role of intracellular calcium changes in cell signaling.1,2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Drumm, B.T., Large, R.J., Hollywood, M.A., et al. The role of Ca2+ influx in spontaneous Ca2+ wave propagation in interstitial cells of Cajal from the rabbit urethra. J. Physiol. 593(15), 3333-3350 (2015).

    2. Jalini, S., Ye, H., Tonkikh, A.A., et al. Raised intracellular calcium contributes to ischemia-induced depression of evoked synaptic transmission. PLoS One 11(3), (2016).

    3. Nanou, E., Sullivan, J.M., Scheuer, T., et al. Calcium sensor regulation of the CaV2.1 Ca2+ channel contributes to short-term synaptic plasticity in hippocampal neurons. Proc. Natl. Acad. Sci. USA 113(4), 1062-1067 (2016).

    Product Citations

    Du, W., Gu, M., Hu, M., et al. Lysosomal Zn2+ release triggers rapid, mitochondria-mediated, non-apoptotic cell death in metastatic melanoma. Cell Rep. 37(3), 109848 (2021).