The major inactive metabolite of LTE4 found in bile
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N-acetyl Leukotriene E4

Item No. 20420

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5S-hydroxy-6R-(S-(N-acetyl)cysteinyl)-7E,9E,11Z,14Z-eicosatetraenoic acid
CAS Number
80115-95-3
Synonyms
  • N-acetyl LTE4
Molecular Formula
C25H39NO6S
Formula Weight
481.6
Purity
≥97%
Formulation (Request formulation change)
A 100 µg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 50 mg/mlEthanol: 50 mg/mlPBS pH 7.2: 0.1 mg/ml
λmax
281 nm
SMILES
CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](NC(C)=O)C(O)=O)[C@@H](O)CCCC(O)=O
InChi Code
InChI=1S/C25H39NO6S/c1-3-4-5-6-7-8-9-10-11-12-13-14-17-23(22(28)16-15-18-24(29)30)33-19-21(25(31)32)26-20(2)27/h7-8,10-14,17,21-23,28H,3-6,9,15-16,18-19H2,1-2H3,(H,26,27)(H,29,30)(H,31,32)/b8-7-,11-10-,13-12+,17-14+/t21?,22-,23+/m0/s1
InChi Key
BGGYAYMMFYBWEX-PJEAHERNSA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    25 µg

    $182

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    50 µg

    $345

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    100 µg

    $652

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    Product Description

    N-acetyl LTE4 is the major inactive metabolite of LTE4 found in bile. This route of metabolism is prominent in the rat, but of minor importance in humans.1,2 N-acetyl LTE4 is 100 times less potent than LTC4 as a vasoconstricting agent.2 In healthy human subjects urinary excretion of N-acetyl LTE4 is about 1.5 nmol/mol creatinine, which is considerably less than that of LTE4 (12 nmol/mol creatinine).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Denzlinger, C., Rapp, S., Hagmann, W., et al. Leukotrienes as mediators in tissue trauma. Science 230, 330-332 (1985).

    2. Foster, A., Fitzsimmons, B., and Letts, L.G. The synthesis of N-acetyl-leukotriene E4 and its effects on cardiovascular and respiratory function of the anesthetized pig. Prostaglandins 31, 1077-1086 (1986).

    3. Huber, M., Müller, J., Leier, I., et al. Metabolism of cysteinyl leukotrienes in monkey and man. Eur. J. Biochem. 194, 309-315 (1990).