A high-affinity fluorescent calcium indicator
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Quin-2 (potassium salt)

Item No. 20421

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-[[8-[bis(carboxymethyl)amino]-6-methoxy-2-quinolinyl]methoxy]-4-methylphenyl]-N-(carboxymethyl)-glycine, tetrapotassium salt
CAS Number
73630-23-6
Molecular Formula
C26H23N3O10 • 4K
Formula Weight
693.9
Purity
≥95%
Emission
492 nm
Excitation
339 nm
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: soluble
SMILES
O=C([O-])CN(CC([O-])=O)C1=C2C(C=CC(COC3=C(N(CC([O-])=O)CC([O-])=O)C=CC(C)=C3)=N2)=CC(OC)=C1.[K+].[K+].[K+].[K+]
InChi Code
InChI=1S/C26H27N3O10.4K/c1-15-3-6-19(28(10-22(30)31)11-23(32)33)21(7-15)39-14-17-5-4-16-8-18(38-2)9-20(26(16)27-17)29(12-24(34)35)13-25(36)37;;;;/h3-9H,10-14H2,1-2H3,(H,30,31)(H,32,33)(H,34,35)(H,36,37);;;;/q;4*+1/p-4
InChi Key
XAGUNWDMROKIFJ-UHFFFAOYSA-J
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $196

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    Product Description

    Quin-2 is a high-affinity fluorescent calcium indicator (Kd = 115 nM for calcium).1 It displays high selectivity for calcium, as it is not affected by sodium gradients, membrane potential, or intracellular pH.1 High affinity probes like quin-2 are ideal for monitoring low levels of calcium, as are found in resting cells.1,2 Loadings of up to 2 mM quin-2 are without serious toxic effects, so quin-2 may be used to buffer intracellular calcium transients. Excitation/emission maxima for quin-2 are 339 and 492 nm, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tsien, R.Y., Pozzan, T., and Rink.T.J. Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator. J. Cell. Biol. 947(2), 325-334 (1982).

    2. Minta, A., Kao, J.P., and Tsien, R.Y. Fluorescent indicators for cytosolic calcium based on rhodamine and fluorescein chromophores. The Journal of Biological Chemisty 264(14), 8171-8178 (1989).