A fluorescent calcium indicator
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BTC (potassium salt)

Item No. 20423

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[3-(2-benzothiazolyl)-6-[2-[2-[bis(carboxymethyl)amino]-5-methylphenoxy]ethoxy]-2-oxo-2H-1-benzopyran-7-yl]-N-(carboxymethyl)-glycine, tetrapotassium salt
CAS Number
216453-54-2
Molecular Formula
C33H25N3O12S • 4K
Formula Weight
844.0
Purity
≥90%
Emission
529 nm
Excitation
401 nm
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
O=C(C(C1=NC2=C(C=CC=C2)S1)=C3)OC4=C3C=C(OCCOC5=C(N(CC([O-])=O)CC([O-])=O)C=CC(C)=C5)C(N(CC([O-])=O)CC([O-])=O)=C4.[K+].[K+].[K+].[K+]
InChi Code
InChI=1S/C33H29N3O12S.4K/c1-18-6-7-22(35(14-28(37)38)15-29(39)40)25(10-18)46-8-9-47-26-12-19-11-20(32-34-21-4-2-3-5-27(21)49-32)33(45)48-24(19)13-23(26)36(16-30(41)42)17-31(43)44;;;;/h2-7,10-13H,8-9,14-17H2,1H3,(H,37,38)(H,39,40)(H,41,42)(H,43,44);;;
InChi Key
NVHVYTMJZUGPBU-UHFFFAOYSA-J
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    BTC is a low affinity calcium indicator (Kd = 7-26 µM) that displays excitation/emission spectra of 401/529 nm, respectively. It exhibits a shift in the excitation maximum from approximately 480 to 401 nm upon calcium binding, enabling determination of ratiometric calcium measurements.1 BTC is suitable for detecting elevated calcium levels associated with activation of smooth muscle, neurons, and intracellular calcium stores.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sabnis, R.W. Handbook of biological dyes and stains: Synthesis and industrial applications. (2010).

    2. Hyrc, K.L., Bownik, J.M., and Goldberg, M.P. Neuronal free calcium measurement using BTC/AM, a low affinity calcium indicator. Cell Calcium 24(3), 165-175 (1998).