An inhibitor of NF-κB
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Dimethylamino Parthenolide

Item No. 20436

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1aR,4E,7aS,8R,10aS,10bR)-8-[(dimethylamino)methyl]-2,3,6,7,7a,8,10a,10b-octahydro-1a,5-dimethyl-oxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one
CAS Number
791595-09-0
Synonyms
  • DMAPT
  • LC-1
Molecular Formula
C17H27NO3
Formula Weight
293.4
Purity
≥99%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: MiscibleDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: MiscibleEthanol: 30 mg/ml
SMILES
O=C([C@H]1CN(C)C)O[C@@]2([H])[C@@]1([H])CC/C(C)=C\CC[C@]3(C)[C@@H]2O3
InChi Code
InChI=1S/C17H27NO3/c1-11-6-5-9-17(2)15(21-17)14-12(8-7-11)13(10-18(3)4)16(19)20-14/h6,12-15H,5,7-10H2,1-4H3/b11-6-/t12-,13-,14-,15+,17+/m0/s1
InChi Key
UJNSFDHVIBGEJZ-WCOQXKCFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $143

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    25 mg

    $301

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    Product Description

    Dimethylamino parthenolide (DMAPT) is an inhibitor of NF-κB and a derivative of parthenolide (Item No. 70080).1 It inhibits the binding of the p65 subunit of NF-κB to DNA by 75% when used at a concentration of 50 µM. DMAPT (25 µM) decreases intracellular glutathione (GSH) levels in, and inhibits the migration of, MDA-MB-231 breast cancer cells. It induces necrosis in MDA-MB-231 cells, an effect that can be reversed by the antioxidant N-acetyl cysteine (Item No. 20261), NADPH oxidase inhibitor apocynin (Item No. 11976), or RIP1 kinase inhibitor necrostatin-1 (Item No. 11658). DMAPT (50 mg/kg) decreases tumor volume in an MDA-MB-231 mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. D'Anneo, A., Carlisi, D., Lauricella, M., et al. Parthenolide generates reactive oxygen species and autophagy in MDA-MB231 cells. A soluble parthenolide analogue inhibits tumour growth and metastasis in a xenograft model of breast cancer. Cell Death Dis. 4(e891), (2013).