A TRPV4 activator
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4α-Phorbol 12,13-didecanoate

Item No. 20446

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
decanoic acid, 1,1'-[(1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-9aH-cyclopropa[3,4]benz[1,2-e]azulene-9,9a-diyl] ester
CAS Number
27536-56-7
Synonyms
  • 4α-PDD
  • 4α-Phorbol 12,13-dicaprinate
Molecular Formula
C40H64O8
Formula Weight
672.9
Purity
≥99%
Formulation
A film
Solubility(Learn about Variance in Solubility)
DMSO: SolubleEthanol: Soluble
SMILES
CC(C1=O)=C[C@]2([H])[C@@]1(O)CC(CO)=C[C@]3([H])[C@]2(O)[C@H](C)[C@@H](OC(CCCCCCCCC)=O)[C@]4(OC(CCCCCCCCC)=O)[C@H]3C4(C)C
InChi Code
InChI=1S/C40H64O8/c1-7-9-11-13-15-17-19-21-32(42)47-36-28(4)39(46)30(24-29(26-41)25-38(45)31(39)23-27(3)35(38)44)34-37(5,6)40(34,36)48-33(43)22-20-18-16-14-12-10-8-2/h23-24,28,30-31,34,36,41,45-46H,7-22,25-26H2,1-6H3/t28-,30+,31-,34-,36-,38+,39-,40-/
InChi Key
DGOSGFYDFDYMCW-OEFRVDPMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $229

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    5 mg

    $1,087

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    Product Description

    4α-Phorbol 12,13-didecanoate is a negative control for phorbol esters, phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) and phorbol 12,13-didecanoate (PDD). Though inactive for signaling through PKC, 4α-phorbol 12,13-didecanoate has been shown to activate transient receptor potential vanilloid 4 (TRPV4) channels.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Watanabe, H., Davis, J.B., Smart, D., et al. Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives. The Journal of Biological Chemisty 277(16), 13569-13577 (2002).