A cell-permeant inhibitor of pre-mRNA splicing
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Madrasin

Item No. 20451

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(7-methoxy-4-methyl-2-quinazolinyl)amino]-5,6-dimethyl-4(3H)-pyrimidinone
CAS Number
374913-63-0
Molecular Formula
C16H17N5O2
Formula Weight
311.3
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMF:PBS (pH7.2) (1:40): 0.025 mg/ml
λmax
217, 253, 306, 330 nm
SMILES
COC(C=C1)=CC2=C1C(C)=NC(NC3=NC(C(C)=C(C)N3)=O)=N2
InChi Code
InChI=1S/C16H17N5O2/c1-8-9(2)17-16(20-14(8)22)21-15-18-10(3)12-6-5-11(23-4)7-13(12)19-15/h5-7H,1-4H3,(H2,17,18,19,20,21,22)
InChi Key
QQJIYKXTEMDJFM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $103

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    10 mg

    $186

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    25 mg

    $420

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    Product Description

    Madrasin is a cell-permeant inhibitor of pre-mRNA splicing.1 It interferes with the early stages of spliceosome assembly and stalls spliceosome assembly at the A complex.1 Madrasin induces cell cycle arrest, promotes a specific reorganization of subnuclear protein localization, and modulates splicing of multiple pre-RNA species in both HeLa and HEK293 cells when used at lower concentrations.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pawellek, A., McElroy, S., Samatov, T., et al. Identification of small molecule inhibitors of pre-mRNA splicing. The Journal of Biological Chemisty 289(50), 34683-34698 (2014).