An inhibitor of PCNA
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PCNA-I1

Item No. 20454

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-methyl-2-[(1-hydroxy-2-naphthalenyl)methylene]hydrazide-2-thiophenecarboxylic acid
CAS Number
444930-42-1
Molecular Formula
C17H14N2O2S
Formula Weight
310.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlDMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
λmax
222, 289, 319, 333, 363 nm
SMILES
OC1=C(/C=N/NC(C2=C(C)C=CS2)=O)C=CC3=CC=CC=C31
InChi Code
InChI=1S/C17H14N2O2S/c1-11-8-9-22-16(11)17(21)19-18-10-13-7-6-12-4-2-3-5-14(12)15(13)20/h2-10,20H,1H3,(H,19,21)/b18-10+
InChi Key
NZWTWRNHYZNWNW-VCHYOVAHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $75

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    10 mg

    $143

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    25 mg

    $333

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    50 mg

    $589

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    Cayman Chemical
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    Product Description

    PCNA-I1 is an inhibitor of proliferating cell nuclear antigen (PCNA) that binds to PCNA trimers (Kd = 0.41 µM) and dose-dependently reduces the level of PCNA associated with chromatin in PC3 cells.1 It preferentially inhibits growth of a variety of human and mouse cancer cell lines (IC50s = 0.05-0.3 µM) over non-transformed cells (IC50s = 0.99-2 µM). PCNA-I1 leads to an accumulation of cells in the G1 phase during the first 24 hours of incubation and halts the cell cycle in the S and G2/M phases by 72 hours following treatment. It also reduces tumor growth in an LNCaP prostate cancer mouse xenograft model when administered at a dose of 10 mg/kg, five days per week, for two weeks.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tan, Z., Wortman, M., Dillehay, K.L., et al. Small-molecule targeting of proliferating cell nuclear antigen chromatin association inhibits tumor cell growth. Mol. Pharmacol. 81(6), (2012).

    2. Dillehay, K.L., Lu, S., and Dong, Z. Antitumor effects of a novel small molecule targeting PCNA chromatin association in prostate cance. Mol. Cancer Ther. 13(12), 2817-2826 (2014).