A cell-permeable form of (R)-2-HG
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TFMB-R-2-HG

Item No. 20461

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2R)-tetrahydro-5-oxo-2-furancarboxylic acid, [3-(trifluoromethyl)phenyl]methyl ester
CAS Number
1445700-01-5
Molecular Formula
C13H11F3O4
Formula Weight
288.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 30 mg/ml
λmax
264, 270 nm
SMILES
O=C([C@H]1CCC(O1)=O)OCC2=CC=CC(C(F)(F)F)=C2
InChi Code
InChI=1S/C13H11F3O4/c14-13(15,16)9-3-1-2-8(6-9)7-19-12(18)10-4-5-11(17)20-10/h1-3,6,10H,4-5,7H2/t10-/m1/s1
InChi Key
UXTLNUGKDZMPTC-SNVBAGLBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $69

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    5 mg

    $280

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    10 mg

    $427

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    Cayman Chemical
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    Product Description

    TFMB-R-2-HG is a cell-permeable form of (R)-2-hydroxyglutarate ((R)-2-HG).1 (R)-2-HG is structurally similar to α-ketoglutarate and competitively inhibits α-ketoglutarate-dependent dioxygenases, including lysine demethylases and DNA hydroxylases.2,3,4 TFMB-R-2-HG has been used to assess the role of (R)-2-HG in leukemogenesis.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Losman, J.A., Looper, R.E., and Koivunen, P. (R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible. Science 339(6127), 1621-1625 (2013).

    2. Yang, H., Ye, D., Guan, K.L., et al. IDH1 and IDH2 mutations in tumorigenesis: Mechanistic insights and clinical perspectives. Clin. Cancer Res. 18(20), 5562-5571 (2012).

    3. Xu, W., Yang, H., Liu, Y., et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell 19(1), 17-30 (2011).

    4. Chowdhury, R., Yeoh, K.K., Tian, Y.M., et al. The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases. EMBO Rep. 12(5), 463-469 (2011).