A fluorogenic dye
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Phalloidin-AMCA Conjugate

Item No. 20463

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Phalloidin-Aminomethylcoumarin Conjugate
Molecular Formula
C47H58N10O13S
Formula Weight
1003.1
Purity
≥90%
Emission
434 nm
Excitation
346 nm
Formulation (Request formulation change)
A solution in DMSO (1000X)
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
NC1=CC=C2C(OC(C(CC(NCC(O)(C)CC(C(NC(C(NC(C(O)C)C(N3)=O)=O)C)=O)NC(C4NC(C(NC(C(CC(O)C5)N5C(C3CSC6=C(C4)C7=C(C=CC=C7)N6)=O)=O)C)=O)=O)=O)=C2C)=O)=C1
InChi Code
InChI=1S/C47H58N10O13S/c1-20-26-11-10-24(48)12-35(26)70-46(68)28(20)15-36(60)49-19-47(5,69)16-32-41(64)50-22(3)39(62)56-37(23(4)58)43(66)54-33-18-71-44-29(27-8-6-7-9-30(27)55-44)14-31(40(63)53-32)52-38(61)21(2)51-42(65)34-13-25(59)17-57(34)45(33)67/h
InChi Key
KMGLGIMFGSJINT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Phalloidin-AMCA conjugate is a fluorescent dye used to label actin filaments (F-actin). Phalloidin binds to F-actin and prevents depolymerization.1 It also inhibits the ATP hydrolysis action of F-actin.2 Phalloidin-AMCA conjugate can be used to label tissue, cells, and cell-free preparations that have been formaldehyde-fixed and permeabilized. It displays excitation/emission maxima of 346/434 nm, respectively. Phalloidin-AMCA conjugate can be used at nanomolar concentrations in conjunction with additional dyes for multi-labeling purposes.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lengsfeld, A.M., Löw, I., Wieland, T., et al. Interaction of phalloidin with actin. Proc. Natl. Acad. Sci. USA 71(7), 2803-2807 (1974).

    2. Löw, I., Dancker, P., and Wieland, T. Stabilization of F-actin by phalloidin. Reversal of the destabilizing effect of cytochalasin B. FEBS Lett. 54(2), 263-265 (1975).