A selective inhibitor of ABCG2
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Product Type

Small Molecule Modulators
Transporter & Exchanger Modulators

Research Area

CAY10719

Item No. 20469

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[1-(3,4-dichlorophenyl)-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl](4-methoxyphenyl)-methanone
CAS Number
1942919-63-2
Molecular Formula
C25H20Cl2N2O2
Formula Weight
451.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS(pH7.2) (1:2): 0.33 mg/mlDMSO: 2 mg/ml
λmax
225 nm
SMILES
COC1=CC=C(C(N2C(C3=CC(Cl)=C(Cl)C=C3)C(NC4=C5C=CC=C4)=C5CC2)=O)C=C1
InChi Code
InChI=1S/C25H20Cl2N2O2/c1-31-17-9-6-15(7-10-17)25(30)29-13-12-19-18-4-2-3-5-22(18)28-23(19)24(29)16-8-11-20(26)21(27)14-16/h2-11,14,24,28H,12-13H2,1H3
InChi Key
AKQFVWUCZTWDKB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $94

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    5 mg

    $160

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    10 mg

    $275

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    25 mg

    $569

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    Product Description

    CAY10719 is a selective inhibitor of the breast cancer resistance protein ABCG2 (IC50 = 0.23 µM) with little activity at ABCG1.1 It has been shown to reverse the ABCG2-mediated resistance toward SN 38 (Item No. 15632) and to inhibit ATPase activity.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Spindler, A., Stefan, K., and Wiese, M. Synthesis and investigation of tetrahydro-β-carboline derivatives as inhibitors of the breast cancer resistance protein (ABCG2). J. Med. Chem. 59(13), 6121-6135 (2016).