A selective 15-PGDH inhibitor
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ML-148

Item No. 20475

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[1-(3-methylphenyl)-1H-benzimidazol-5-yl]-1-piperidinyl-methanone
CAS Number
451496-96-1
Molecular Formula
C20H21N3O
Formula Weight
319.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS (pH 7.2) (1:1): 0.5 mg/mlDMSO: 5 mg/mlEthanol: 10 mg/ml
λmax
213, 242 nm
SMILES
O=C(C1=CC=C(N(C2=CC=CC(C)=C2)C=N3)C3=C1)N4CCCCC4
InChi Code
InChI=1S/C20H21N3O/c1-15-6-5-7-17(12-15)23-14-21-18-13-16(8-9-19(18)23)20(24)22-10-3-2-4-11-22/h5-9,12-14H,2-4,10-11H2,1H3
InChi Key
YQNOQZALLOQMPY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $41

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    1 mg

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    5 mg

    $312

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    Product Description

    ML-148 is an inhibitor of 15-hydroxy prostaglandin dehydrogenase (15-PGDH) with an IC50 value of 56 nM.1 It demonstrates selectivity for 15-PGDH when profiled across a panel of related dehydrogenase or reductase enzymes.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Niesen, F.H., Schultz, L., Jadhav, A., et al. High-affinity inhibitors of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase: Mechanisms of inhibition and structure-activity relationships. PLoS One 5(11), e13719 (2010).