A fluorescent probe for Aβ
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Methoxy-X04

Item No. 20476

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,4'-[(2-methoxy-1,4-phenylene)di-(1E)-2,1-ethenediyl]bis-phenol
CAS Number
863918-78-9
Molecular Formula
C23H20O3
Formula Weight
344.4
Purity
≥95%
Emission
460-500 nm
Excitation
750 nm (2-photon excitation)
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:2): 0.33 mg/mlEthanol: 5 mg/ml
λmax
371 nm
SMILES
OC1=CC=C(/C=C/C2=CC=C(/C=C/C3=CC=C(O)C=C3)C(OC)=C2)C=C1
InChi Code
InChI=1S/C23H20O3/c1-26-23-16-19(3-2-17-6-12-21(24)13-7-17)5-11-20(23)10-4-18-8-14-22(25)15-9-18/h2-16,24-25H,1H3/b3-2+,10-4+
InChi Key
FGYNZFHVGOFCMD-KHVHPYDTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

    $120

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    10 mg

    $186

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    Product Description

    Methoxy-X04 is a brain-permeable fluorescent probe for amyloid-β (Aβ) to detect and quantify plaques, tangles, and cerebrovascular amyloid.1 It displays high in vitro binding affinity (Ki = 26.8 nM) for fibrillar β-sheet deposits and is used to image Aβ plaques in the brains of living APP/PS1 mice, a transgenic model of familial Alzheimer's disease.1,2 For in vivo imaging, APP/PS1 mice were injected with methoxy-X04 at a dose of 10 mg/kg, i.p., 24 hours prior to two-photon imaging.2 Methoxy-X04 displays an excitation peak at 750 nm with emission between 460 and 500 nm.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Klunk, W.E., Backsai, B.J., Mathis, C.A., et al. Imaging Aβ plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative. J. Neuropathol. Exp. Neurol. 61(9), 797-805 (2002).

    2. Burgold, S., Bittner, T., Dorostkar, M.M., et al. In vivo multiphoton imaging reveals gradual growth of newborn amyloid plaques over weeks. Acta. Neuropathol. 121(3), 327-335 (2011).