An anthelmintic agent
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Labeled Version(s)
30237Praziquantel-d11
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Praziquantel

Item No. 20508

Technical Information
Formal Name
2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one
CAS Number
55268-74-1
Synonyms
  • Embay 8440
  • (±)-Praziquantel
Molecular Formula
C19H24N2O2
Formula Weight
Purity
≥98%
A crystalline solid
DMF: 30 mg/mlDMSO: 20 mg/mlDMSO:PBS(pH 7.2) (1:4): 0.2 mg/mlEthanol: 10 mg/ml
SMILES
O=C(N1CC(C(C=CC=C2)=C2CC3)N3C(C1)=O)C4CCCCC4
InChi Code
InChI=1S/C19H24N2O2/c22-18-13-20(19(23)15-7-2-1-3-8-15)12-17-16-9-5-4-6-14(16)10-11-21(17)18/h4-6,9,15,17H,1-3,7-8,10-13H2
InChi Key
FSVJFNAIGNNGKK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    Praziquantel is an anthelmintic agent.1,2 It is lethal to S. mansoni schistosomula and adults (LC50s = 0.68 and 0.03 mg/ml, respectively).2 Praziquantel (172 and 592 mg/kg) reduces worm burden in a mouse model of S. mansoni infection. Formulations containing praziquantel have been used in the treatment of schistosomiasis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cook, G.C. Anthelminthic agents: Some recent developments and their clinical application. Postgrad. Med. J. 67(783), 16-22 (1991).

    2. Olliaro, P., Delgado-Romero, P., and Keiser, J. The little we know about the pharmacokinetics and pharmacodynamics of praziquantel (racemate and R-enantiomer). J. Antimicrob. Chemother. 69(4), 863-870 (2014).