An intermediate in carbohydrate metabolism
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Product Categories

Product Type

Biochemicals

Research Area

Endocrinology & Metabolism
Carbohydrate Metabolism

D-Fructose-1,6-bisphosphate (sodium salt hydrate)

Item No. 20516

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,6-bis(dihydrogen phosphate)-D-fructose, trisodium salt, octahydrate
CAS Number
81028-91-3
Synonyms
  • D-Fructose-1,6-diphosphate
Molecular Formula
C6H11O12P2 • 3Na [8H2O]
Formula Weight
550.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
SMILES
O[C@H]([C@@H](COP([O-])([O-])=O)O)[C@@H](C(COP([O-])(O)=O)=O)O.[Na+].[Na+].[Na+].O.O.O.O.O.O.O.O
InChi Code
InChI=1S/C6H14O12P2.3Na.8H2O/c7-3(1-17-19(11,12)13)5(9)6(10)4(8)2-18-20(14,15)16;;;;;;;;;;;/h3,5-7,9-10H,1-2H2,(H2,11,12,13)(H2,14,15,16);;;;8*1H2/q;3*+1;;;;;;;;/p-3/t3-,5-,6-;;;;;;;;;;;/m1.........../s1
InChi Key
BUMXRRGJJDMPRT-PESUWTOCSA-K
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 g

    $28

    Add

    5 g

    $53

    Add

    10 g

    $73

    Add

    25 g

    $129

    Add
    Product Description

    D-Fructose-1,6-bisphosphate is an intermediate in carbohydrate metabolism, including glycolysis and gluconeogenesis. During glycolysis, it is generated by the phosphorylation of fructose-6-phosphate by phosphofructokinase. The reverse reaction, mediated by fructose-1,6-bisphosphatase-1, is one of the rate-limiting steps in gluconeogenesis.1,2 The same reaction occurs within chloroplasts in plants as part of the reductive pentose phosphate cycle.3 Because cancer cells adopt glycolysis as a major source of metabolic energy production, this pathway has become a major target for cancer chemotherapy.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Marcus, F., and Hosey, M.M. Purification and properties of liver fructose 1,6-bisphosphatase from C57BL/KsJ normal and diabetic mice. The Journal of Biological Chemisty 255(6), 2481-2486 (1980).

    2. Van Den Berghe, G. Disorders of gluconeogenesis. J. Inherit. Metab. Dis. 19(4), 470-477 (1996).

    3. Wolosiuk, R.A., Ballicora, M.A., and Hagelin, K. The reductive pentose phosphate cycle for photosynthetic CO2 assimilation: Enzyme modulation. FASEB J. 7(8), 622-637 (1993).

    4. Seo, M., Kim, J.D., Neau, D., et al. Structure-based development of small molecule PFKFB3 inhibitors: A framework for potential cancer therapeutic agents targeting the Warburg effect. PLoS One 6(9), e24179 (2011).