A CysLT produced in vitro from LTE4
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Leukotriene F4

Item No. 20520

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5S-hydroxy-6R-(S-γ-glutamylcysteinyl)-7E,9E,11Z,14Z-eicosatetraenoic acid
CAS Number
83851-42-7
Synonyms
  • LTF4
Molecular Formula
C28H44N2O8S
Formula Weight
568.7
Purity
≥97%
Formulation (Request formulation change)
A 100 µg/ml solution in methanol
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 50 mg/mlEthanol: 50 mg/mlPBS pH 7.2: 0.1 mg/ml
λmax
280 nm
SMILES
CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](NC(CC[C@H](N)C(O)=O)=O)C(O)=O)[C@@H](O)CCCC(O)=O
InChi Code
InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22
InChi Key
PYSODLWHFWCFLV-BJAXAWPRSA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    25 µg

    $147

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    50 µg

    $277

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    100 µg

    $522

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    Product Description

    LTF4 is a cysteinyl-leukotriene produced in vitro, but not reported to date in vivo. It is formed by the incubation of LTE4 with γ-glutamyl transpeptidase and glutathione. LTF4 is a weak agonist in its ability to contract vascular smooth muscle.1 The rank order of potency of the cysteinyl-leukotrienes to contract vascular smooth muscle is LTD4 > LTC4 > LTE4 >> LTF4.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bernstrom, K., and Hammarström, S. A novel leukotriene formed by transpeptidation of leukotriene E4. Biochem. Biophys. Res. Commun. 109, 800-804 (1982).

    2. Lord, A., Charleson, S., and Letts, L.G. Leukotriene F4 and the release of arachidonic acid metabolites from perfused guinea pig lungs in vitro. Prostaglandins 29, 651-660 (1985).