A LeuRS inhibitor
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AN3365 (hydrochloride)

Item No. 20572

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[[(3S)-3-(aminomethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaborol-7-yl]oxy]-1-propanol, monohydrochloride
CAS Number
1234563-16-6
Synonyms
  • Epetraborole
  • GSK2251052
Molecular Formula
C11H16BNO4 • HCl
Formula Weight
273.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 10 mg/ml
λmax
230, 284 nm
SMILES
OB1O[C@H](CN)C2=CC=CC(OCCCO)=C21.Cl
InChi Code
InChI=1S/C11H16BNO4.ClH/c13-7-10-8-3-1-4-9(16-6-2-5-14)11(8)12(15)17-10;/h1,3-4,10,14-15H,2,5-7,13H2;1H/t10-;/m1./s1
InChi Key
DADYQGIQOBJGIW-HNCPQSOCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $41

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    5 mg

    $157

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    10 mg

    $293

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    25 mg

    $631

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    Product Description

    AN3365 is an inhibitor of leucyl-tRNA synthetase (LeuRS; IC50 = 0.31 µM for the E. coli enzyme).1 It is active against a variety of Gram-negative and Gram-positive bacteria, including E. coli, E. faecalis, S. epidermidis, S. pneumoniae, and S. pyogenes (MICs = 4, 8, 2, 2, and 2 µg/ml, respectively), as well as a panel of multidrug-resistant (MDR) clinical isolates of the Gram-negative bacteria A. baumannii, Enterobacteriaceae, and P. aeruginosa (MICs = 0.5-4, 0.5-2, and 1-4 µg/ml, respectively). AN3365 inhibits protein, RNA, DNA, and fatty acid synthesis in E. coli (IC50s = 8.3, 105, 366, and 396 µg/ml, respectively). It reduces the number of colony forming units (CFUs) in neutropenic mouse thigh models of E. coli or P. aeruginosa infection when administered at a dose of 30 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hernandez, V., Crépin, T., Palencia, A., et al. Discovery of a novel class of boron-based antibacterials with activity against gram-negative bacteria. Antimicrob. Agents and Chemother. 57(3), 1394-1403 (2013).