An ionophorous antibiotic
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Monazomycin

Item No. 20589

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
48-(7-amino-1-methylheptyl)-8,10,16,20,24,26,28,32,36,38,40,42,44,46-tetradecahydroxy-23-(α-D-mannopyranosyloxy)-9,15,17,19,21,25,31,33,39,41,47-undecamethyl-oxacyclooctatetraconta-13,17,21,29-tetraen-2-one
CAS Number
11006-31-8
Synonyms
  • Takacidin
  • U-0142
Molecular Formula
C72H133NO22
Formula Weight
1364.8
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: SolubleDMSO: SolubleEthanol: SolubleMethanol: Soluble
SMILES
OC(CC(C(C(C(O[C@@H]1[C@@H](O)[C@@H](O)[C@H](O)C(CO)O1)/C=C(C)/C(O)C(C)/C=C(C)/C(O)C(C)/C=C/CCC(O)C(C)C(O)CCCCCC2=O)O)C)O)/C=C/C(C)C(O)C(C)CCC(O)CC(O)C(C)C(O)C(C)C(O)CC(O)CC(O)C(C)C(O2)C(C)CCCCCCN
InChi Code
InChI=1S/C72H133NO22/c1-39-22-19-20-25-55(79)46(8)54(78)24-17-15-18-26-62(84)95-71(42(4)23-16-13-14-21-31-73)50(12)59(83)37-53(77)36-58(82)48(10)66(88)47(9)56(80)34-51(75)29-27-40(2)63(85)41(3)28-30-52(76)35-57(81)49(11)67(89)60(33-45(7)65(87)44(6)32
InChi Key
BTUZNIQVZBANAX-MFDVZNRISA-N
Origin
Bacterium/Streptomyces sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Monazomycin is a macrocyclic polyol lactone first isolated from Streptoverticillium that is active against Gram-positive bacteria. In solution, monazomycin exists as hydrophilic clusters that, when adsorbed onto a lipid bilayer, can induce voltage-dependent conductance.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Andersen, O.S., and Muller, R.U. Monazomycin-induced single channels. I. Characterization of the elementary conductance events. J. Gen. Physiol. 80(3), 403-426 (1982).

    2. Muller, R.U., Orin, G., and Peskin, C.S. The kinetics of monazomycin-induced voltage-dependent conductance. I. Proof of the validity of an empirical rate equation. J. Gen. Physiol. 78(2), 171-200 (1981).