An autoregulative inhibitor of spore germination
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Germicidin B

Item No. 20591

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-ethyl-4-hydroxy-6-(1-methylethyl)-2H-pyran-2-one
CAS Number
150973-78-7
Molecular Formula
C10H14O3
Formula Weight
182.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: SolubleDMSO: SolubleEthanol: SolubleMethanol: Soluble
SMILES
O=C1OC(C(C)C)=CC(O)=C1CC
InChi Code
InChI=1S/C10H14O3/c1-4-7-8(11)5-9(6(2)3)13-10(7)12/h5-6,11H,4H2,1-3H3
InChi Key
SZBDLUWYHDLLAG-UHFFFAOYSA-N
Origin
Bacterium/Streptomyces sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $193

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    Product Description

    Germicidin B is a pyranone antibiotic originally derived from Streptomyces. It acts as a reversible, autoregulative inhibitor of spore germination and hyphal elongation in the genus Streptomyces at concentrations as low as 200 pM.1,2 During germination, spores of Streptomyces excrete germicidin B along with other germicidin homologs, which inhibit germination of its own arthrospores.1,2 At higher concentrations, germicidin can inhibit the porcine brain Na+/K+-dependent ATPase (ID50 = 100 µM) and prevent the germination of the cress L. sativum.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Petersen, F., and Zähner, H. Germicidin, an autoregulative germination inhibitor of Streptomyces viridochromogenes NRRL B-1551. J. Antibiot. (Tokyo) 46(7), 1126-1138 (1993).

    2. Aoki, Y., Matsumoto, D., Kawaide, H., et al. Physiological role of germicidins in spore germination and hyphal elongation in Streptomyces coelicolor A3(2). J. Antibiot. (Tokyo) 64(9), 607-611 (2016).