A leptomycin B analog
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Anguinomycin A

Item No. 20598

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
19-(3,6-dihydro-6-oxo-2H-pyran-2-yl)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoic acid
CAS Number
111278-01-4
Synonyms
  • 5-Demethylleptomycin A
Molecular Formula
C31H44O6
Formula Weight
512.7
Purity
≥95%
Formulation (Request formulation change)
A film
Solubility(Learn about Variance in Solubility)
DMSO: UnstableEthanol: SolubleMethanol: Soluble
SMILES
O=C1OC(/C=C/C(C)=C/C(C)C/C=C/C(C)=C/C(C)C(C(C)C(O)C(C)C/C(C)=C/C(O)=O)=O)CC=C1
InChi Code
InChI=1S/C31H44O6/c1-20(16-22(3)14-15-27-12-9-13-29(34)37-27)10-8-11-21(2)17-24(5)30(35)26(7)31(36)25(6)18-23(4)19-28(32)33/h8-9,11,13-17,19-20,24-27,31,36H,10,12,18H2,1-7H3,(H,32,33)/b11-8+,15-14+,21-17+,22-16+,23-19+
InChi Key
SGYKTDIJCLHSET-QMTWAXRBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    100 µg

    $359

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    500 µg

    $1,612

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    Product Description

    Anguinomycin A is an antibiotic first isolated from a Streptomyces sp. and analog of leptomycin B (Item No. 10004976) that is highly cytotoxic to mouse P388 leukemia cells in vitro (IC50 = 0.1-0.2 ng/ml).1 It also demonstrates antitumor activity at 62.5 µg/kg/day against Lewis lung carcinoma in mice.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hayakawa, Y., Adachi, K., and Komeshima, N. New antitumor antibiotics, anguinomycins A and B. J. Antibiot. (Tokyo) 40(9), 1349-1352 (1987).